Objectives Understanding the molecular changes in the preclinical synovium is crucial for identifying factors that drive ...

Scientists have created a live-cell DNA sensor that reveals how damage appears and disappears inside living cells, capturing the entire repair sequence as it unfolds. Instead of freezing cells at ...

Genome instability can cause numerous diseases. Cells have effective DNA repair mechanisms at their disposal. A research team has now gained new insights into the DNA damage response. Whenever cells ...

Lymphocyte Infiltration Score and Spatial Characteristics Refined the Prognosis and Denosumab Treatment Responsiveness Indicators for Giant Cell Tumor of Bone Outcomes data for DNA-damaging ...

Illustration showing how autophagy induction increases the efficiency of precise gene editing. In normal cells, DNA breaks caused by CRISPR–Cas9 are frequently repaired through non-homologous end ...

New study shows that in women with BRCA1 or BRCA2 mutations, their breast cells already carry a clear pattern of DNA “damage ...

A research team has successfully identified a novel DNA damage repair pathway in human cells. This study is the first to discover that proteins present in the nuclear membrane of cells directly ...

The human genome consists of 3 billion base pairs, and when a cell divides, it takes about seven hours to complete making a copy of its DNA. That's almost 120,000 base pairs per second. At that ...

Bowel cancer cells have the ability to regulate their growth using a genetic on-off switch to maximize their chances of survival, a phenomenon that's been observed for the first time by researchers at ...