引言在细胞每一次分裂、每一次应对内外环境挑战的喧嚣中，我们的基因组(genome)正经历着持续的修订、涂抹甚至撕裂。在癌症和许多先天性疾病的基因组中，我们常常能看到一些令人匪夷所思的混乱景象：染色体片段的诡异扩增、莫名其妙的序列插入、以及如同地震后断壁残垣般的复杂结构重排(complex ...

DNA replication is a fundamental process essential for bacterial growth and survival. Initiation begins at the chromosomal origin (oriC), where the conserved initiator protein DnaA assembles into an ...

A new LUMC study has changed our understanding of how cells work. Researchers have discovered that the CFAP20 protein acts as ...

非洲猪瘟是由ASFV引起的猪烈性传染病，具有高致死率，自2018年传入我国以来，已造成巨大经济损失，严重威胁全球养猪业安全。由于ASFV基因组庞大复杂，编码蛋白众多，且缺乏有效抗病毒药物和商业化疫苗，其防控一直是全球兽医领域的重大难题。病毒DNA聚合酶作为基因组复制的核心“引擎”，是抗病毒药物开发的关键靶点，但ASFV的DNA聚合酶的复制机制此前尚未被完全解析。

DNA doesn’t just sit still inside our cells — it folds, loops, and rearranges in ways that shape how genes behave.

King Abdullah University of Science & Technology (KAUST)Mar 19 2025 For the first time, scientists have witnessed the very moment DNA begins to unravel, revealing a necessary molecular event for DNA ...

Scientists at the University of Leicester have captured the first detailed "molecular movie" showing DNA being unzipped at the atomic level – revealing how cells begin the crucial process of copying ...

Non-coding DNA is essential for both humans and trypanosomes, despite the large evolutionary divergence between these two species.

A new LUMC study has changed our understanding of how cells work. Researchers have discovered that the CFAP20 protein acts as ...

This transcript has been edited for clarity. For more episodes, download the Medscape app or subscribe to the podcast on Apple Podcasts, Spotify, or your preferred podcast provider. Dr Liu is a ...

A Northwestern Medicine study has revealed a previously unknown connection between two fundamental cellular processes, ...