Background Aortic stenosis (AS) frequently coexists with heart failure (HF), but its prevalence, prognostic impact and management across the full HF spectrum remain incompletely characterised. Methods ...

Correspondence to Dr Stephen F Weng, Primary Care Stratified Medicine (PRISM), Division of Primary Care, University Park Campus, University of Nottingham, Nottingham NG7 2RD, UK ; ...

Cardiac device therapy has significantly evolved since the introduction of the first implantable pacemaker and the subsequent ...

Objective Transitions in the spectrum of valvular heart diseases (VHDs) in developed countries over the 20th century have been reported from clinical case series, but large, contemporary ...

Correspondence to Dr Prachi Bhatnagar, British Heart Foundation Centre on Population Approaches for Non-Communicable Disease Prevention, Nuffield Department of Population Health, Old Road Campus, ...

Isolated tricuspid regurgitation (TR) can be caused by primary valvular abnormalities such as flail leaflet or secondary annular dilation as is seen in atrial fibrillation, pulmonary hypertension and ...

Objective ACE inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are widely prescribed in patients with high cardiovascular (CV) risk. However, whether both classes have equivalent ...

Background Heart auscultation is a widely used and cost-effective clinical tool for detecting valvular heart disease (VHD), particularly in primary care. However, existing evidence on its diagnostic ...

Mitral annular calcification (MAC) is a progressive, degenerative process increasingly recognised for its clinical impact.

Context: International guidelines recommend the routine use of oxygen therapy in the treatment of myocardial infarction (MI). Objective: To undertake a systematic review and meta-analysis of ...

MicroRNAs (miRNAs) are small, non-coding, RNA molecules approximately 22 nucleotides in length which act as post-transcriptional regulators of gene expression. Individual miRNAs have been shown to ...

Background Menopause is a timely opportunity to screen for cardiovascular disease (CVD) and intervene with healthier lifestyles. We investigated the association between premature/early menopause and ...