Skin cancer often begins quietly with tiny mutations inside skin cells. Ultraviolet light, chemicals, or repeated irritation slowly damage DNA, but early changes are small and invisible. The skin keeps repairing itself, and the immune system removes many abnormal cells, allowing mutations to build unnoticed. Over time, some damaged cells begin dividing faster than normal. A patch of skin may thicken, a mole may darken, or edges may turn uneven, changes that are often ignored. When mutations reac

Cancer cells are highly flexible and can change their behavior as they move through different environments in the body. New research shows that physical pressure around a tumor can trigger internal changes that push these cells away from rapid growth and toward a more invasive and treatment resistant state. These changes do not come from permanent DNA damage but from epigenetic shifts that alter how DNA is organized and accessed inside the cell nucleus. Using zebrafish models of melanoma, resear